PTD-DBM

Also known as Protein Transduction Domain–Dishevelled Binding Motif, CXXC5-Dvl disrupting peptide

A cell-penetrating peptide that disrupts the CXXC5–Dishevelled interaction to activate Wnt/β-catenin signaling, studied topically for hair regrowth.

Molecular weight~3080.7 g/mol

Half-lifeNot well characterized; a topically applied peptide with presumed short tissue residence. Treat as uncertain.

CategoryCosmetic

Typical use cases

✓ Hair-regrowth research✓ Wnt/β-catenin pathway activation✓ Wound-healing / follicle neogenesis models

Dosing guidelines

StartingResearch is topical. Source work used ~2 mM PTD-DBM applied to skin, often paired with valproic acid as a Wnt activator.

MaintenanceTopical scalp application typically once daily in research/anecdotal use; no standardized human regimen exists.

Max (studied)No validated upper bound in humans; hedge and keep to low topical concentrations.

Titration

No established titration; used at a fixed topical concentration, sometimes co-applied with valproic acid or methyl vanillate.

Reconstitution

Commonly sold as a 5 mg lyophilized vial; for topical research it is dissolved in bacteriostatic water or a carrier solution and applied to the scalp (not typically injected).

Injection sites

Topical application to the scalp/skin; not an injectable in typical research use.

Storage & handling

Lyophilized: stable months cool/dark, longer frozen. Reconstituted: refrigerate (2–8 °C).

Side effects

Scalp irritation / itching (topical) Mild · Uncommon
Contact dermatitis Mild · Rare
Unknown long-term effects (sparse human data) Moderate · Rare

Research summary

PTD-DBM is a synthetic peptide that links a protein-transduction domain to a Dishevelled-binding motif, blocking CXXC5's negative regulation of Wnt/β-catenin signaling. In mouse studies, topical PTD-DBM induced hair regrowth and wound-induced hair-follicle neogenesis, and combination with valproic acid outperformed minoxidil in those models. Evidence is preclinical (rodent/in vitro); human efficacy and safety are not established, and it is not an approved drug. Educational only — not medical advice.

Key references

Lee et al., J. Invest. Dermatol. (2017) — CXXC5/Dishevelled disruption (PTD-DBM) and hair regrowth

Related compounds

GHK-Cu → GHK →

Where to buy

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Educational reference only — not medical advice. Dosing figures are commonly-cited ranges, not prescriptions. Consult a qualified clinician.

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